Several theories have been suggested for the lack of correlation between anatomical features and central fatigue. Many early studies failed to identify an association between MS-related fatigue and either the total global extent of cerebral abnormalities or lesions in regional areas 5, 6, 7, 8. Advanced quantitative magnetic resonance imaging (MRI) techniques allow for objective assessment of disease pathology and have been used to characterize the pathophysiology of central fatigue in MS, but many questions remain regarding the anatomic brain correlate of fatigue.įew papers have examined white matter lesion load (WM-LL) in relation to fatigue. The precise mechanisms causing fatigue in MS patients are complex and poorly understood and may differ between patients. Fatigue has direct impact on the quality of life, and patient’s disability 4. It is defined as difficulty initiating or sustaining voluntary activities and is accompanied by a feeling of disproportionate effort 2, 3. In conclusion, EDSS and infratentorial lesion volume (cerebellar and brainstem) are the best predictors of fatigue severity.įatigue is one of the most important and disabling symptoms of multiple sclerosis (MS) patients 1 and occurs in 80% of cases with relapsing remitting multiple sclerosis (RRMS). Ordinal regression analysis for fatigue severity showed EDSS and infratentorial lesion volume were the best predictors. Whole brain volume, total and regional WM-LL (juxtacortical, periventricular, infratentorial) were also correlated with fatigue severity. Age, disease duration, relapses, and EDSS were positively correlated to fatigue severity ( P = 0.034, 0.002, 0.009 and 0.001 respectively). 33.3% of patients had no significant fatigue, 25.4% had mild-to-moderate fatigue, and 41.3% had significant fatigue. The patients were classified into three groups: no fatigue (FSS 5). VolBrain, a fully automated, operator-independent tool was used to assess WM-LL and whole brain volume. Each patient provided demographic details and was scored on the expanded disability status scale (EDSS) and fatigue severity scale (FSS). 63 patients with RRMS participated in this study mean age was 31.9 ± 8.1 years. Here we assess the relation between fatigue and regional WM-LL volumetric measures. Many studies have linked grey matter atrophy to fatigue, but white matter lesion load (WM-LL) has received less attention. America's #1 Correction Brand - *Source: The NPD Group, Inc./ U.S.Fatigue is a common disabling symptom of relapsing remitting multiple sclerosis (RRMS).Multi-purpose Wite Out quickly covers errors.One 1-count pack of BIC Wite-Out Brand Quick Dry Correction Fluid, 20mL.Retail Tracking Service/ Actual Unit Product Line Sales (Retail & Commercial Combined)/ Jan - Dec 2021 America's #1 Correction Brand - *Source: The NPD Group/ U.S. This pack contains one 20 ml bottles of white out liquid correction fluid. The included applicator is easy to use, while the reduced drying time means you don't have to wait to organize or file your documents after making corrections.

From America's #1 Correction Brand,* this bright white quick-drying correction liquid works on handwritten and printed ink, faxes, and photocopies like whiteout tape and white out pen. Quickly and easily correct errors on your school and work documents with BIC Wite-Out Brand Quick Dry Correction Fluid.

Off white correction fluid